Vizz Is FDA-Approved
It all begins with an idea.
Blog Entry – July 31, 2025
Introducing Vizz: New Daily Eye Drop for Blurry Near Vision (Presbyopia)
If you’re one of the many people over 45 struggling to read small print, use smartphones comfortably, or see up close without holding items at arm’s length—you’re in good company. Fortunately, there’s promising news: Vizz (aceclidine ophthalmic solution 1.44 %) is now FDA-approved for the treatment of presbyopia in adults, offering a potential game-changer for near-vision clarity. (Medscape)
📊 Trial Snapshot
Vizz’s approval was built on three randomized, double-masked Phase 3 trials—named CLARITY 1, 2 and 3—conducted by LENZ Therapeutics.
CLARITY 1 and 2 enrolled 466 adults with presbyopia, treated once-daily for 42 days. (WebMD)
CLARITY 3 enrolled 217 adults for long-term safety over six months of daily dosing. (Medical Xpress)
Altogether, more than 30,000 treatment days of data were submitted. (Drugs.com)
🧪 Methods
Participants were administered one drop of Vizz once daily (in each eye, a second drop two minutes later per prescribing information) and compared with control treatments (placebo or alternate drop) in masked fashion. Near‐vision acuity was measured at multiple time-points (30 minutes, several hours, up to 10 hours) to assess onset and duration of effect. Importantly, distance vision was monitored to ensure it was not compromised. (WebMD)
✅ Key Results
Rapid onset: Within 30 minutes, approximately 65 %–71 % of Vizz users achieved a ≥3-line improvement in near visual acuity without losing a line of distance vision. In CLARITY 1: 65 % vs ~12 % in control; in CLARITY 2: 71 % vs ~8 %. (WebMD)
Duration: In both trials, up to 40 % of participants maintained improved near vision after 10 hours of dosing. (WebMD)
Distance vision preserved: No meaningful reduction in distance acuity was observed.
Long-term data: In the six-month safety trial, no new concerns emerged.
⚠️ Safety & Side Effects
The safety profile of Vizz was favorable. No serious treatment-related adverse events were reported across all three trials. (Medical Xpress) The most commonly reported side-effects included:
Instillation-site irritation (≈20 %)
Dim vision (≈16 %)
Headache (≈13 %)
Conjunctival hyperemia (≈8 %)
Ocular hyperemia (≈7 %) (LENZ Therapeutics, Inc.)
Most events were mild, transient and resolved without intervention. However, the prescribing information highlights the need for baseline retinal examination, as there is a rare risk of retinal tear/detachment with miotic agents. (FDA Access Data)
📝 Conclusions
For adults dealing with age-related blurry near vision, Vizz represents an important new option. The once-daily drop offers rapid onset of improvement, meaningful duration (up to 10 hours), and a strong safety profile. Since its approval, Vizz promises greater flexibility and fewer reliance on reading glasses for many patients.
As always, a discussion with your eye-care provider remains essential to determine if Vizz fits your individual vision needs and health status.
Stay tuned for availability in U.S. pharmacies (anticipated fall 2025) and ask our practice how you can get started.
This blog entry is for informational purposes only and does not replace an eye-care consultation. Always follow the prescribing information and advice of your physician.
Vizz Arrives to U.S. Pharmacies
Blog Entry – October 1, 2025
Vizz Now Available at U.S. Pharmacies: What Patients Should Know
We’re excited to share that Vizz™ (aceclidine ophthalmic solution 1.44 %) is now making its way into U.S. pharmacies — both local retail and online options — following its July 31 2025 approval by the U.S. Food & Drug Administration (FDA). Drugs.com+3Ophthalmology Times+3Drugs.com+3
📦 What This Means for You
Commercial samples of Vizz began shipping in October 2025, with broad availability expected by mid-Q4. Pharmacy Times+2LENZ Therapeutics, Inc.+2
Vizz offers adults with Presbyopia a once-daily prescription drop that improves near-vision clarity for up to 10 hours while preserving distance vision. WebMD+1
The drop is available by prescription only — you’ll need a valid script from a physician and fulfillment through your preferred pharmacy.
🧪 Why Pharmacy Availability Matters
Until now, your near-vision options were largely limited to reading glasses, multifocal contacts, or surgical procedures. With Vizz’s arrival, patients now have a pharmacological option for near-vision clarity that fits into daily life. As one commentator noted:
“This marks a disruptive paradigm shift in treatment options for millions of people who are frustrated and struggling with the inevitable age-related loss of their near vision.” Pharmacy Times+1
✅ What to Do Before Going to the Pharmacy
Discuss Vizz with your eye-care provider to determine if it’s appropriate for you.
Obtain a prescription, then select a pharmacy — many sites allow you to search and filter for local or mail-order fulfillment.
Ask your pharmacy for current pricing and availability, as costs may vary and initial supply may be limited regionally.
Once you have your vial, follow the dosage instructions: one drop in each eye, wait two minutes, then a second drop in each eye — once per day. FDA Access Data
⚠️ Safety Notes & Typical Side-Effects
In large Phase 3 trials (CLARITY 1 & 2: 466 participants; CLARITY 3: 217 participants), Vizz was well-tolerated with no serious treatment-related events. Epocrates+1 Common side-effects included:
Instillation-site irritation (~20 %)
Dim or dark vision (~16 %)
Headache (~13 %)
Managed Healthcare Executive+1
Because Vizz causes pupil constriction (a pinhole effect), you will want to avoid driving until your vision clears after instillation. Also, inform your provider if you have retinal issues, iritis, or recent eye surgery, as such conditions were excluded in trials. FDA Access Data
🌟 Final Thoughts
The availability of Vizz in pharmacies represents an important milestone for anyone dealing with blurry near vision. With once-daily dosing, a strong clinical data set, and broad rollout underway, it’s a treatment option worth exploring — especially if you’re tired of constantly relying on reading glasses.
If you’re interested in starting treatment, talk to our practice today about how Vizz might fit into your vision-care plan.
This blog entry is for educational purposes only and not intended as medical advice. Always consult your eye-care provider before starting any new prescription treatment.