Reid Brackin 12/1/25 Reid Brackin 12/1/25

Qlosi vs Vuity vs Vizz

Blog Entry - December 1, 2025

A Simple Guide to Today’s Presbyopia Eye Drops

If you’re over 40 and noticing you need to hold your phone farther away to read, you are not alone. This happens to everyone — it’s called presbyopia. Now, there are prescription eye drops that can help you see up close without constantly reaching for readers.

The three main options are:

Vuity
Qlosi
Vizz

They all work by making the pupil smaller to sharpen near vision, but they differ in strength, duration, and how they are used. Here’s an easy guide to help you compare them.

🌟 Quick Comparison Table

Feature	Vuity	Qlosi	Vizz
Active ingredient	Pilocarpine 1.25%	Pilocarpine 0.4%	Aceclidine 1.44%
How fast it works	⭐ ~15 min	⭐⭐ ~15–20 min	⭐⭐ ~30 min
How long it lasts	⭐⭐ ~6 hours	⭐⭐ 6–8 hours (with 2 doses)	⭐⭐⭐ Up to ~10 hours
Dosing	1 drop once daily	1 drop once or twice daily	1 drop once daily
Peak effectiveness	Moderate	Moderate–Strong	Strongest of the three in published studies
Night-vision dimming	⚠️ Yes	⚠️ Yes	⚠️ Yes
Learn more at:	https://www.vuity.com	https://www.qlosi.com	https://www.vizz.com

⭐ = good
⭐⭐ = very good
⭐⭐⭐ = excellent

📘 The Three Drops Explained

👓 Vuity

What it is: The first FDA-approved eye drop for presbyopia.
How it works: Shrinks the pupil and slightly activates the eye’s focusing system (accommodation).
Typical benefit: Works in about 15 minutes; lasts around 6 hours.

More info:
https://www.vuity.com
Prescribing info: https://www.rxabbvie.com/pdf/vuity_pi.pdf

👓 Qlosi

What it is: A lower-dose pilocarpine option with flexible dosing.
How it works: Shrinks the pupil with a comfort-oriented formulation.
Typical benefit: Works in 15–20 minutes; lasts up to 8 hours if a second dose is used.

More info:
https://www.qlosi.com
Provider info: https://www.qlosiecp.com

👓 Vizz

What it is: A once-daily, pupil-selective presbyopia drop using aceclidine.
How it works: Creates a strong “pinhole effect” for near vision without significantly straining the eye’s focusing muscles.
Typical benefit: Improves near vision within ~30 minutes; many users maintain near-vision clarity for up to 10 hours based on published trial results.

More info:
https://www.vizz.com
https://www.vizz.com/prescribing-information

🧠 “Which one is the best?”

There are no direct head-to-head studies, so no drop can claim an official win. But based on each product’s published clinical data:

Vuity – Good improvement, established track record, once daily.
Qlosi – Similar improvement to Vuity, with flexible twice-daily dosing.
Vizz – Across published studies, Vizz showed the highest proportion of patients with strong near-vision improvement and the longest duration of effect (often up to ~10 hours). This makes Vizz appealing for people who want one drop that lasts through most of the workday.

🌙 Side Effects

All three drops may cause:

Mild headache
Eye redness or irritation
“Dim” vision in low light
Temporary distance blur after instillation

These effects come from the pupil becoming smaller. Most side effects are mild and fade as the drop wears off.

👍 Simple Recommendations

Choose Vuity if you want the original once-daily option.
Choose Qlosi if you want flexible twice-a-day dosing and a familiar pilocarpine base.
Choose Vizz if you want the strongest and longest-lasting near-vision improvement based on published clinical trial data.

📲 Want To Compare Them Yourself?

Reid Brackin 11/12/25 Reid Brackin 11/12/25

Where to Find Vizz

Blog Entry - November 12, 2025

Many patients have asked recently where they can obtain Vizz™ (phentolamine ophthalmic solution 0.75%), since availability has been somewhat limited. We received an update today from a representative at Lenz Therapeutics, the company that manufactures Vizz, and wanted to share the latest information.

At this time, Vizz is guaranteed to be available through a home delivery pharmacy called Up Script Pharmacy. Up Script is based in Utah but ships Vizz directly to patients across the country. The medication is shipped at room temperature. Once received by a patient, Vizz should be stored in the refrigerator.

Patients can conveniently manage prescriptions, make payments, and schedule delivery directly through the Up Script website:
👉 https://www.upscriptpharmacy.com/

I hope this update makes it easier to locate and order Vizz if you’ve been having difficulty finding it locally. As always, please let me know if we can assist with a prescription for Vizz or answer any questions about treatment options.

Registration for the medical practice through this website is free. There are no monthly fees or any costs to message the medical provider through the link on this website. Please contact us if you think Vizz might be right for you.

Reid Brackin 10/1/25 Reid Brackin 10/1/25

Vizz Arrives to U.S. Pharmacies

Blog Entry – October 1, 2025

Vizz Now Available at U.S. Pharmacies: What Patients Should Know

We’re excited to share that Vizz™ (aceclidine ophthalmic solution 1.44 %) is now making its way into U.S. pharmacies — both local retail and online options — following its July 31 2025 approval by the U.S. Food & Drug Administration (FDA). Drugs.com+3Ophthalmology Times+3Drugs.com+3

📦 What This Means for You

Commercial samples of Vizz began shipping in October 2025, with broad availability expected by mid-Q4. Pharmacy Times+2LENZ Therapeutics, Inc.+2
Vizz offers adults with Presbyopia a once-daily prescription drop that improves near-vision clarity for up to 10 hours while preserving distance vision. WebMD+1
The drop is available by prescription only — you’ll need a valid script from a physician and fulfillment through your preferred pharmacy.

🧪 Why Pharmacy Availability Matters

Until now, your near-vision options were largely limited to reading glasses, multifocal contacts, or surgical procedures. With Vizz’s arrival, patients now have a pharmacological option for near-vision clarity that fits into daily life. As one commentator noted:

“This marks a disruptive paradigm shift in treatment options for millions of people who are frustrated and struggling with the inevitable age-related loss of their near vision.” Pharmacy Times+1

✅ What to Do Before Going to the Pharmacy

Discuss Vizz with your eye-care provider to determine if it’s appropriate for you.
Obtain a prescription, then select a pharmacy — many sites allow you to search and filter for local or mail-order fulfillment.
Ask your pharmacy for current pricing and availability, as costs may vary and initial supply may be limited regionally.
Once you have your vial, follow the dosage instructions: one drop in each eye, wait two minutes, then a second drop in each eye — once per day. FDA Access Data

⚠️ Safety Notes & Typical Side-Effects

In large Phase 3 trials (CLARITY 1 & 2: 466 participants; CLARITY 3: 217 participants), Vizz was well-tolerated with no serious treatment-related events. Epocrates+1 Common side-effects included:

Instillation-site irritation (~20 %)
Dim or dark vision (~16 %)
Headache (~13 %)
Managed Healthcare Executive+1
Because Vizz causes pupil constriction (a pinhole effect), you will want to avoid driving until your vision clears after instillation. Also, inform your provider if you have retinal issues, iritis, or recent eye surgery, as such conditions were excluded in trials. FDA Access Data

🌟 Final Thoughts

The availability of Vizz in pharmacies represents an important milestone for anyone dealing with blurry near vision. With once-daily dosing, a strong clinical data set, and broad rollout underway, it’s a treatment option worth exploring — especially if you’re tired of constantly relying on reading glasses.
If you’re interested in starting treatment, talk to our practice today about how Vizz might fit into your vision-care plan.

This blog entry is for educational purposes only and not intended as medical advice. Always consult your eye-care provider before starting any new prescription treatment.

Reid Brackin 7/31/25 Reid Brackin 7/31/25

Vizz Is FDA-Approved

It all begins with an idea.

Blog Entry – July 31, 2025

Introducing Vizz: New Daily Eye Drop for Blurry Near Vision (Presbyopia)

If you’re one of the many people over 45 struggling to read small print, use smartphones comfortably, or see up close without holding items at arm’s length—you’re in good company. Fortunately, there’s promising news: Vizz (aceclidine ophthalmic solution 1.44 %) is now FDA-approved for the treatment of presbyopia in adults, offering a potential game-changer for near-vision clarity. (Medscape)

📊 Trial Snapshot

Vizz’s approval was built on three randomized, double-masked Phase 3 trials—named CLARITY 1, 2 and 3—conducted by LENZ Therapeutics.

CLARITY 1 and 2 enrolled 466 adults with presbyopia, treated once-daily for 42 days. (WebMD)
CLARITY 3 enrolled 217 adults for long-term safety over six months of daily dosing. (Medical Xpress)
Altogether, more than 30,000 treatment days of data were submitted. (Drugs.com)

🧪 Methods

Participants were administered one drop of Vizz once daily (in each eye, a second drop two minutes later per prescribing information) and compared with control treatments (placebo or alternate drop) in masked fashion. Near‐vision acuity was measured at multiple time-points (30 minutes, several hours, up to 10 hours) to assess onset and duration of effect. Importantly, distance vision was monitored to ensure it was not compromised. (WebMD)

✅ Key Results

Rapid onset: Within 30 minutes, approximately 65 %–71 % of Vizz users achieved a ≥3-line improvement in near visual acuity without losing a line of distance vision. In CLARITY 1: 65 % vs ~12 % in control; in CLARITY 2: 71 % vs ~8 %. (WebMD)
Duration: In both trials, up to 40 % of participants maintained improved near vision after 10 hours of dosing. (WebMD)
Distance vision preserved: No meaningful reduction in distance acuity was observed.
Long-term data: In the six-month safety trial, no new concerns emerged.

⚠️ Safety & Side Effects

The safety profile of Vizz was favorable. No serious treatment-related adverse events were reported across all three trials. (Medical Xpress) The most commonly reported side-effects included:

Instillation-site irritation (≈20 %)
Dim vision (≈16 %)
Headache (≈13 %)
Conjunctival hyperemia (≈8 %)
Ocular hyperemia (≈7 %) (LENZ Therapeutics, Inc.)
Most events were mild, transient and resolved without intervention. However, the prescribing information highlights the need for baseline retinal examination, as there is a rare risk of retinal tear/detachment with miotic agents. (FDA Access Data)

📝 Conclusions

For adults dealing with age-related blurry near vision, Vizz represents an important new option. The once-daily drop offers rapid onset of improvement, meaningful duration (up to 10 hours), and a strong safety profile. Since its approval, Vizz promises greater flexibility and fewer reliance on reading glasses for many patients.
As always, a discussion with your eye-care provider remains essential to determine if Vizz fits your individual vision needs and health status.

Stay tuned for availability in U.S. pharmacies (anticipated fall 2025) and ask our practice how you can get started.

This blog entry is for informational purposes only and does not replace an eye-care consultation. Always follow the prescribing information and advice of your physician.